"Normally, PINK1 and Parkin work together to mark damaged mitochondria for removal by adding a chain of molecules called ubiquitin. This mark allows proteins called autophagy adaptors to associate ...

Many researchers working in areas outside autophagy, such as signalling, membrane trafficking, and ubiquitin-related processes, as well as researchers interested in various aspects of physiology ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

Hyun remarks: "Inhibiting the activity of ubiquitin specific peptidase 14 (USP14), a component of the proteasome complex, with IU1 enhanced not only proteasome activity but also autophagy activity ...

Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules – the ubiquitin code – which ...

Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

Different types of programmed cell death. This picture summarizes the different pathways of programmed cell death (Note: ROS: reactive oxygen species). By unveiling the complex interactions ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and ...