This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...
Autophagy and apoptosis may be triggered by ... or p150 in humans) participate. Two ubiquitin-like conjugation systems are part of the vesicle elongation process (step 3). One pathway involves ...
In addition, TBK1 directly phosphorylates the selective autophagy receptors p62 and OPTN, which are crucial for autophagic clearance of ubiquitin-coated bacteria. Figure 6 Multiple modes of autophagy ...
This will encompass discussing protein translation, folding and maintenance by chaperones, post-translational modifications, and the two main proteolytic mechanisms: the ubiquitin-proteasome (UPS) and ...
Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...
This study aims to investigate the role of organelle-specific autophagy in rodent brain ischemia models. Methods: Rats and mice were subjected to either sham surgery, 20 min of global ischemia, or ...
The DF-O and MPs samples suppressed autophagy by decreasing expression levels of microtubule-associated protein light chain 3 (LC3B), p-phosphatidylinositol 3-kinase (p-PI3K), phosphorylated AKT ...
1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...
That these three closely connected pathways—microbial signalling (NOD2), autophagy and ER stress—are all linked with IBD and affect Paneth cell function clearly suggests that bacterial handling plays ...
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