The sequence context of UBDs and the conformational ... are modified following various cellular stimuli) to effector proteins (ubiquitin receptors containing one or more UBDs) have been elucidated ...

is different from those of ubiquitin-like molecules, such as neuronal precursor cell expressed developmentally downregulated protein 8 (NEDD8), in which the C-terminal sequence is Leu-Ala-Leu-Arg ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Akribion Therapeutics emerges from stealth with €8 million in seed funding to develop a novel cancer RNA-guided approach ...

(F) Sequence alignment of U-box domains in ... His-TEV-HsUbcH5a, His-TEV- (Tetra-ubiquitin) and His-Strep-TEV-HsUbiquitin the cell lysates over expressing the proteins were prepared as above. After ...

Based on their functional domains and ubiquitin transfer mechanisms, these poxvirus-encoded E3 ubiquitin ligases and adaptor proteins can be divided into ... the C-terminal 13 amino acid F-box-like ...

Telomerase is a reverse transcriptase enzyme complex capable of adding DNA sequence repeats (TTAGGG ... Reactive Oxygen Species; SIAH1, E3 ubiquitin-protein ligase SIAH1; TBK1, TANK-binding kinase 1; ...

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

For the first time, researchers used data from protein shapes and combined it with data from genomic sequences to improve the reliability of evolutionary trees—which they describe as a critical ...