Herein, we developed a novel computational fragment generation and coupling (CFGC) strategy that led to a series of highly potent and bioselective inhibitors targeting protoporphyrinogen IX oxidase.

Patients with hyperuricemia reportedly have endothelial dysfunction, which could be restored by reducing serum urate levels with a xanthine oxidase (XO) inhibitor, allopurinol (Allo). However, it ...