Pulmonary arterial hypertension (PAH) is an increasingly understood disease, with the genetics and pathophysiology mapped out to the extent that new therapies are emerging.1 The epidemiology, however, ...

Few treatments have revolutionised care for people with chronic inflammatory disorders more than biologic and small molecule ...

The case of avian influenza A (H5) confirmed by the Centers for Disease Control and Prevention in Missouri, USA, on Sept 6, 2024,1 has reignited concerns about the risk of human contagion and the need ...

In 2013, 9-year-old Ella Roberta Adoo Kissi Debrah died following a severe asthma attack. Soon after, her family began to ...

In an era of technological advancement and artificial intelligence, emotions experienced by patients and health professionals are often overlooked. Shame is a powerful emotion that many clinicians ...

The global polio eradication hinges on timely reporting of polioviruses and rapid responses. Despite considerable efforts made during the past three decades to contain polio, the WHO African (AFRO) ...

The Global Antibiotic Research and Development Partnership aims to stimulate research for much-needed new antibiotics. Talha Burki reports.

Cholera is a waterborne disease caused by Vibrio cholerae bacteria of the serogroups 01 and 139, usually occurring due to inadequate access to safe drinking water, sanitation, and hygiene. This ...

More than ever, the climate crisis is becoming a health crisis. An estimated 5 million people globally die each year because ...

Rustam Al-Shahi Salman is head of the cerebrovascular group, honorary consultant neurologist, and clinical director of the clinical trials unit at the University of Edinburgh (Edinburgh, UK), where he ...

The COMBO-MS trial, reported in The Lancet Neurology by Tiffany Braley and colleagues,1 is the first pragmatic, randomised, controlled trial that compares head-to-head the benefits and harms of a ...

Tenecteplase is a third-generation thrombolytic agent that has a favourable pharmacological profile, compared with alteplase. Tenecteplase has a longer half-life, which allows administration in a ...