The dense cell culture environment can exacerbate cellular stress, increasing the likelihood of tRNA mispairing or ribosomal inaccuracies ... While trypsin is typically used to cleave proteins at ...

Compared with cysteine-targeting strategies, lysine serves as an alternative covalent binding site that circumvents the limitation of cysteine scarcity in ligand-binding pockets and broadens the ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

They looked at small RNA molecules called tRNA fragments, which help control gene expression. Remarkably, the stress impacted whole families of tRNA fragments, especially those from mitochondrial DNA.

We have all heard of messenger RNA (mRNA) by now, but what about transfer RNA (tRNA)? Well, there is a growing awareness that this emerging technology is capable of a myriad of biological functions ...

In addition, the proteins are easily labeled with [35S]-methionine or biotinylated lysine simply by addition of the labeling reagent to the reaction. Unfo ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The alkanediol 1,6-hexanediol has been widely ...

Recent advancements in single-molecule biophysics have been driven by breakthroughs in advanced fluorescence microscopy techniques and the development of next-generation organic fluorophores. These ...