A study of human tumor cells implanted in mice from the MacPherson Lab at Fred Hutch describes a new way to screen for the ...

There is a consistent need from researchers to manufacture a cGMP virus to support the advancement of gene therapies.

Primary endpoint met in R/R mNPM1 AML patients in pivotal Phase 2 portion of the AUGMENT-101 trial – – Robust remission rates in heavily pre-treated R/R mNPM1 AML population with nearly 50% overall ...

This useful study explores the role of RAP2A in asymmetric cell division (ACD) regulation in glioblastoma stem cells (GSCs), drawing parallels to Drosophila ACD mechanisms and proposing that an ...

Princess Margaret Cancer Center at University Health Network-led researchers constructed a detailed single-cell atlas of ...

A highly sensitive bone marrow test could double survival rates for some groups of younger adults with Acute Myeloid Leukemia (AML) by helping doctors identify if they might relapse up to three months ...

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These metabolic pathways were further enriched in TP53-m AML blasts when compared to CH and healthy stem cells, suggesting a switch in energy metabolism associated with myeloid lineage commitment. AML ...

T cell bispecific antibodies (TCBs) activate T cells solely through CD3 engagement, bypassing co-stimulatory pathways. However, the efficacy of TCB-mediated cytotoxicity against acute myeloid leukemia ...

In both MDS and AML where there is tri-lineage failure, what has happened to the normal cells? Are they dormant or have they been extinguished? The loss of normal cells migh be due to different ...

Though AML is a genetically heterogeneous disease, all its subtypes share a common feature: impaired differentiation of myeloid progenitor cells in the bone marrow. This differentiation block results ...