One quick line from Alex Karev in Grey's Anatomy paid off 4 years later when Callie and Arizona fought for custody of their daughter.

Alex Karev starred in 343 episodes of Grey's Anatomy during his 16-year run on the show. Justin Chambers has also seen a ton of success through his work on Grey's Anatomy, proving that even though ...

Sixteen seasons in, "Grey's Anatomy" still knows how to shock its audience – even though, in retrospect, we should've seen that coming. ABC promised us the March 5 episode would be Alex Karev's ...

As showrunner Krista Vernoff wrote on Twitter: It is nearly impossible to say goodbye to Alex Karev. That is as true for me and for all of the writers at Grey’s Anatomy as it is for the fans.

To Meredith, Alex begins ... when Karev was a machismo jerk hitting on anyone that could still breathe — to their later years, as their friends' paths took them away from Grey Sloan and left ...

Justin Chambers was great as Alex Karev on the Grey’s Anatomy cast. Pic credit: ABC How Grey’s Anatomy dealt with the departure of Alex Karev is not sitting well with a lot of fans.

Grey's Fanatics were abuzz when we learned how the veteran series would write out Alex Karev, and shortly into Grey's Anatomy Season 16 Episode 16, we learned that Alex didn't go to Iowa.

While fans reel from the sudden news that Justin Chambers has left Grey’s Anatomy after 15 years and 16 seasons as Dr. Alex Karev — and won’t be getting the epic, heartbreaking sendoff one ...

Would it be better or worse for Alex's legacy as a character if he died or abandoned everything without even saying goodbye on screen? The March 5 episode of Grey's Anatomy will serve as Alex's ...

And Alex’s wife, Jo Karev (Camilla Luddington), stole a ... fans with a string of unanswered questions. Naturally, Grey’s Anatomy fans are trying to predict how Alex’s storyline will end ...

Grey's Anatomy referenced Alex Karev again in its latest episode in the US, but some fans found the moment a little awkward. Original cast member Justin Chambers exited the popular medical drama ...