Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

The pairing of a tRNA to its compatible mRNA sequence within the ribosome is the basis for the translation of RNA into protein. The editing domains of AlaRS (AlaRS-Ed) and ThrRS (ThrRS-Ed ...