H&E stain. Credit: Wikipedia/CC BY-SA 3.0 Multiple myeloma is a type of blood cancer caused by a buildup of abnormal plasma cells in the bone marrow.

Mechanistically, glutaminolysis provides amino acids and nucleotides which are essential for osteoclast differentiation and bone resorption in vitro. Genetic experiments in mice found that ...

Several therapeutic agents to address bone loss act by inhibiting osteoclast-mediated bone resorption are available ... Synovium and/or bone in these samples were examined by H&E staining and ...

H & E staining has revealed a relatively greater destruction ... In the dynamic equilibrium relationship between bone resorption and bone formation, the higher the RANKL/OPG ratio, the stronger the ...

After removing cells with deionized water, resorption pit formation was visualized by von Kossa staining and the resorptive area was ... Serial paraffin sections (2 μm) were stained for H&E and ...

1 School of Life Sciences, Shanghai University, Shanghai, China 2 Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, ...

Imbalances in bone formation and resorption cause osteoporosis. Mounting evidence supports that brain-derived neurotrophic factor (BDNF) implicates in this process. 7,8-Dihydroxyflavone (7,8-DHF), a ...

Marrow adipose tissue (MAT) has been shown to be vital for regulating metabolism and maintaining skeletal homeostasis in the bone marrow (BM) niche. As a reflection of BM remodeling, MAT is highly ...

Bone marrow adipose lineage cells are essential RANKL sources for trabecular osteoclast formation and bone resorption in the context of pathological bone loss. The Adipoq Cre line targets bone marrow ...

Previous studies suggest microbiota are detrimental to bone by increasing resorption. In this report, we show that the gut resident microbiota promote bone formation, as well as resorption, with ...