Frontiers21d
Prospect of extracellular vesicles in tumor immunotherapy
Extracellular vesicles (EVs), as cell-derived small vesicles, facilitate intercellular communication within the tumor microenvironment (TME) by transporting biomolecules. EVs from different sources ...
Frontiers7mon
Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development
Mice were treated daily with or without gilteritinib, an inhibitor of Fms-like tyrosine kinase 3 (Flt3), (SelleckChem, Houston, TX, USA; 200 μg/mouse) (23) by oral gavage using 20-gauge, 1.5-inch ...
eLife6y
The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activation induces the expression of numerous genes, with many effects on cells. However, AhR activation is not ...
eLife9y
Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are ...