Epilepsy is primarily treated symptomatically—that is, the majority of the available medications aim to suppress seizures ...

Epilepsy is primarily treated symptomatically - that is, the majority of the available medications aim to suppress seizures ...

A series of tight binding carbonic anhydrase (CA) activators was obtained by reaction ... CA I, II, and IV. Very good activity was detected against hCA I and bCA IV (h = human; b = bovine isozymes), ...

After the administration of a single dose of the drug to this patient, the urine was examined for carbonic anhydrase inhibitor activity. Seventy-two per cent of the administered drug was recovered ...

Sulfonamides inhibit the catalytic activity of carbonic anhydrases (CAs, EC 4.2.1.1), enzymes participating in the regulation of acid−base balance and ion transport in many tissues. Carbonic anhydrase ...

Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved ... This study aimed to develop a novel 4-pyridyl analog (Pyr) of SLC-0111 with enhanced anticancer activity. Methods: ...

Human carbonic anhydrases (hCAs) have been recognized as suitable ... Consequently, the inhibition of hCAs combined to the possibility to modulate the activity of a second molecular target represents ...

Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea Division of Bio-Medical Science and Technology, KIST School, University of Science and ...