Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the ...

Lipid membranes, which form the outer layer of cells, can be engineered to influence cellular functions. For example, ...

But recent research points to an unexpected ally in this fight: the common cholesterol-lowering drugs known as statins. A hidden enemy in cancer’s spread The biggest threat from cancer usually ...

Study: Cholesterol and ceramide facilitate ... the lipid content of the outer leaflet of plasma membranes more closely. Since it is known that high membrane curvature stimulates fusion, the ...

In support of this, the scientists also found that depletion of Niemann-Pick C1 protein (NPC1)—which transports cholesterol to the plasma membrane—opened the cytosolic floodgates for tau. Mutations in ...

In eukaryotes, cholesterol is a structural lipid of the cellular membrane. Changes in the ratio of cholesterol content in the plasma membrane (PM) regulates the BK channel activation altering its open ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cholesterol is essential for cell physiology.

From these findings, it seems that many drugs that inhibit fusion do so by removing cholesterol from the plasma membrane. Since this involves the plasma membrane of the virus, containing the spike ...

Specifically, VEGF‐B signaling impairs recycling of low‐density lipoprotein receptor (LDLR) to the plasma membrane, leading to reduced cholesterol uptake and membrane cholesterol loading. Reduced ...

Cholesterol is a major structural component of the plasma membrane (PM). The majority of PM cholesterol forms complexes with other PM lipids, making it inaccessible for intracellular transport.