Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders ...

For most of us, getting less than seven hours of sleep translates into grogginess, sluggish thinking, and an overwhelming ...

Conclusions FSTL1 is a potent regulator of chondrocyte proliferation, differentiation and expression of ECM molecules. Our findings may lead to the development of novel strategies for cartilage repair ...

The results of this study will indicate if a growth environment enhanced with the SCM and bFGF will lead to increased human chondrocyte proliferation while maintaining differentiation potential.

Sulfated glycosaminoglycans (GAGs), which are found in the native extracellular matrix, are known to interact with growth factors and, thus, promote chondrocyte function ... pSC and SS enhanced MSC ...

Methods High throughput screening of 170 000 compounds identified a small molecule gp130 modulator termed regulator of cartilage growth and differentiation (RCGD ... RCGD 423 greatly reduced ...

chondrogenic differentiation of MSCs and chondrocyte-to-osteoblast transdifferentiation also play important roles in endochondral ossification and can both be regulated by many of the same types of ...

rather than direct chondrocyte transformation, is supported by the observation that in vitro coculture of MSCs with chondrocytes results in upregulation of collagen matrix formation, despite only ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...