This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation ...

1 Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Zhejiang, China Objectives Epigenetic mechanisms have been reported to play key ...

Objectives To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular ...

At Microsoft, we are dedicated to helping our customers accelerate AI Transformation by empowering human ambition with Copilots and agents, developing differentiated AI solutions and building scalable ...

The results of this study will indicate if a growth environment enhanced with the SCM and bFGF will lead to increased human chondrocyte proliferation while maintaining differentiation potential.

Figure 1. Chondrocytes originate from MSCs and undergo a series of differentiation processes. Sox9 induces MSCs differentiate into chndrocytes and promotes proliferation, whereas Runx2 stimulates ...

The profiled open chromatin regions recapitulate known chondrocyte and skeletal biology, are enriched at height GWAS loci, particularly near differentially expressed growth plate genes, and enriched ...