Stanford Medicine researchers sifted through thousands of single nucleotide mutations in DNA to identify fewer than 400 that are functionally associated with inherited cancer risk.
CMRI researchers discovered that DNA repair pathways control how cancer cells die after radiotherapy. Blocking a key repair ...
The mammalian DNA repair process has evolved over time into a number of complex pathways to cope with all of the alterations that can occur to the structure of DNA. The past 30 years have seen a ...
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Inherited cancer risk: Large-scale screen homes in on 380 variantsThousands of single changes in the nucleotides that make up the human genome have been associated with an increased risk of ...
Our cells constantly receive DNA damage from factors such as ultraviolet rays, irradiations, toxins and chemicals. For women, ...
Pfizer Inc. today announced positive results from the Phase 3 TALAPRO-2 study of TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide ...
A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or ...
Scientists at Children’s Medical Research Institute (CMRI) have solved a big mystery in cancer research – why cells die in ...
Fortunately, life has evolved sophisticated pathways to repair damaged DNA, collectively termed the ‘DNA Damage Response’, and in humans this system is crucial for supressing tumour initiation.
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