A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

In 2012, scientists Jennifer Doudna and Emmanuelle Charpentier replicated this mechanism found in microbes to develop a ...

This landmark study describes the structure of the human RAD51 filament with a recombination intermediate called the displacement loop (D-loop). Using cryogenic structural, biochemical, and ...

“This is the first step towards the use of gene editing therapies to treat a wide variety of rare genetic disorders for which there are currently no definitive medical treatments,” said Dr. Kiran ...

In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read like a recipe to build a protein. But there's more to the story. Some RNA ...

The paper describes how alternative structures called flipons set the reading frame to make RNA from DNA. A three-stranded triplex structure creates an open region where DNA is unwrapped.

To link aptamers to DNA strand displacement modules, various methods such as structure-switching aptamers, associative toeholds, hidden toeholds, remote toeholds, transient toeholds, chemical ligation ...

By Livia Albeck-Ripka Reporting from Los Angeles Los Angeles County will retest about 4,000 DNA samples connected to criminal cases after discovering that it had been using potentially defective ...

Before this study, Pol-theta's structure had only been captured ... "Human polymerase θ helicase positions DNA microhomologies for double-strand break repair," include Yonghong Bai, Brian A.

a similar approach to making biosensors was developed using a single DNA strand rather than a DNA origami structure. That earlier work was led by Kevin W. Plaxco (PhD '94) of UC Santa Barbara ...