San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

Detroit's defensive injuries will probably catch up to them in the postseason, but the 49ers don't look to have enough in the ...

The Detroit Lions and San Francisco 49ers face off Monday night in a game that certainly means more to Detroit. Not only will ...

The Lions held a 17-point lead in the NFC championship game over the San Francisco 49ers before getting outscored 27-7 in the ...

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Monday Night Football game between Detroit Lions ...

Shawn Hochuli, son of longtime former referee Ed Hochuli, will preside over Monday's game as the lead official. It will be the second Lions game he's worked this season, with the first being Detroit's ...

The Detroit Lions can breath a sign of relief after getting some positive indicators ahead of the team's 49ers game.

Coach Dan Campbell stood at the podium after Detroit blew a 17-point lead to San Francisco in last season's NFC title game ...

If the Vikings beat the Packers on Sunday, the Lions can clinch the NFC North with a win in Week 18 no matter what they do vs ...

The Detroit Lions won't face Christian McCaffrey in Week 17 this season. The San Francisco 49ers running back injured the PCL in his knee, an MRI confirmed Monday, and San Francisco plans to place ...