C&EN17d
Tunable Integrin–Ligand Coupling Strength Modulates Cellular Adaptive Mechanosensing
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P.R. China Bioinspired Engineering ...
C&EN17d
Mapping Tumor–Stroma–ECM Interactions in Spatially Advanced 3D Models of Pancreatic Cancer
Centre for 3D models of Health and Disease, Division of Surgery and Interventional Science, University College London, London W1W 7TY, U.K. Centre for 3D models of Health and Disease, Division of ...
eLife1mon
Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model
This study presents a valuable nonlinear mathematical model that addresses how cell shape transitions in response to ECM stiffness. The evidence supporting the claims of the authors is solid, although ...
Frontiers9mon
Microglial Piezo1 mechanosensitive channel as a therapeutic target in Alzheimer’s disease
The presence of Aβ plaques in the brain is sufficient for the establishment of a mechanical gradient that enables microglial durotaxis. Microglia lacking Piezo1 release fewer proinflammatory cytokines ...
Frontiers2y
Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity
Collective cell migration on extracellular matrix (ECM) networks is a key biological process involved in development, tissue homeostasis and diseases such as metastatic cancer. During invasion of ...