Normally, TDP-43 mostly operates in the nucleus, binding RNA to guide splicing and ... Chief among them were the PIAS E3 ligases (also identified by Carra’s group, see below) and the SUMO-targeted ...

N6-methyladenosine (m6A) is one such mechanism, where methyl groups are added to the N6 position of adenosine on RNA. Adding these ... is mediated by E3 ubiquitin ligases, the team further ...

FTO drew attention in the field of obesity even before its role in RNA modification was fully ... of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified ...

Single-cell RNA sequencing (scRNA-seq ... Importantly, AUCell analysis revealed that CHIP E3 ubiquitin ligase activity deficiency affected ubiquitin-mediated proteolysis, ultimately increasing the ...

The E3 Ubiquitin Protein Ligase CBL B pipeline drugs market research report outlays comprehensive information on the E3 Ubiquitin Protein Ligase CBL B targeted therapeutics, complete with analysis by ...

DTX3L, a member of the DELTEX family E3 ubiquitin ligases, ubiquitylates DNA and RNA in vitro and that this activity is shared with DTX3, but not with the other DELTEX family members DTX1, DTX2 and ...

In the ciliated protozoan Tetrahymena, the interaction between Piwi-associated small RNAs (scnRNAs) and the nascent lncRNA transcripts from the somatic genome has been proposed to induce ...

Ubiquitin modification of proteins plays a common role ... Not only restricted in the degradation of substrates, an RNA-binding E3 ligase, mex-3 RNA binding family member C (MEX3C), catalyzed protein ...

E3 ubiquitin–protein ligases transfer activated ubiquitin from ubiquitin-conjugating ... Next, the function of RNF223 in the PC cell lines ASPC-1 and PANC-1 was investigated using shRNA-mediated RNA ...

WWP1 (WW domain–containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related ... AAV9 carrying cardiac troponin T (cTnT) promoter–driven small hairpin RNA targeting WWP1 ...