G protein–coupled receptors (GPCRs) are a protein superfamily comprising >800 members that regulate numerous cellular and physiologic responses. GPCRs represent the largest class of therapeutic ...

A study by the Leibniz Institute for Food Systems Biology at the Technical University of Munich shows that less ...

Background Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) is a severe autoimmune disorder with high morbidity and mortality. Current treatments have limitations including relapse, ...

‡ State Key Laboratory for Oxo Synthesis & Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China § State Key Laboratory of Applied Organic ...

Get Instant Summarized Text (Gist) A novel GPS NMR method enabled precise tracking of motions within the β 1-adrenergic GPCR, revealing that the receptor exists in a dynamic equilibrium among ...

Now, scientists at the Salk Institute have pinpointed a set of transcription factors—estrogen-related receptors (ERRs)—as essential regulators of mitochondrial metabolism in skeletal muscle ...

In this phase 2, randomized, placebo-controlled trial, participants with narcolepsy type 1 received once- or twice-daily oveporexton (TAK-861), an oral orexin receptor 2–selective agonist ...

kDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands lDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical ...

These findings could pave the way for developing pharmacological treatments targeting estrogen-related receptors (ERRs) to improve mitochondrial energy metabolism and combat human diseases associated ...

Timing and Outcomes of Palliative Care Integration Into Care of Adolescents and Young Adults With Advanced Cancer The advent of next-generation antibody-drug conjugates (ADCs), particularly ...