The study, published in Nature, found that special gut cells, called enterochromaffin (EC) cells, play a more significant role in pain than previously thought, by detecting harmful stimuli and ...

Circulating serotonin is produced in the duodenum by enterochromaffin cells, specialized endocrine cells in the epithelia lining the gut, and functions within a specialized neuroendocrine network.

Enterochromaffin (EC) cells and expression of leptin, PAX4 (critical factor for EC specification), tryptophane hydroxylase-1 (TPH1, the peripheral rate-limiting enzyme for 5HT) and 5HT were ...

However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. See full labeling. Highly emetogenic chemotherapy ...