More information: Nick J. Spencer et al, Identification of vagal afferent nerve endings in the mouse colon and their spatial relationship with enterochromaffin cells, Cell and Tissue Research (2024).

Enterochromaffin (EC) cells and expression of leptin, PAX4 (critical factor for EC specification), tryptophane hydroxylase-1 (TPH1, the peripheral rate-limiting enzyme for 5HT) and 5HT were ...

Circulating serotonin is produced in the duodenum by enterochromaffin cells, specialized endocrine cells in the epithelia lining the gut, and functions within a specialized neuroendocrine network.