Vapourtec’s R-Series flow chemistry system, equipped with a UV-150 photochemical reactor, has been cited in research by scientists* at Novo Nordisk in the C-terminal α-amination of peptides and ...

Peptide therapy enhances targeted medicine, utilizing specific peptides for effective treatment of cancer, metabolic disorders, and neurodegenerative diseases.

It has recently been suggested, on the basis of two sequence fingerprints, G(X) 5 HXH(X) 11 G and G(X) 5 P(X) 4 H(X) 3 N (where X is any amino acid residue ... EC 1.2.3.4) to H 2 O 2 is linked ...

Scientists at Novo Nordisk have demonstrated a photochemically enabled strategy for the functionalisation of peptides and ...

(1,2) Peptides mimicking natural hormones (GLP-1/GnRH derived peptide drugs), those derived ... Peptidomimetics and chemical modifications of the natural amino acid containing peptide sequences to ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Peptides and proteins are crucial in maintaining biological ...

Rat insulinoma INS-1 cells are widely used to study insulin secretory mechanisms. Studies have shown that a population of INS-1 cells are bi-hormonal, co-expressing insulin, and proglucagon proteins.

Tryptophan is catabolized along the kynurenine pathway through the action of two enzymes that mediate the first and rate-limiting step of the pathway: indoleamine 2,3-dioxygenase ... only a low ...

(2) Oxidative stress ... cardiac fatty acid oxidation has been shown to improve cardiac function and metabolic status. Natural substances such as resveratrol, the traditional Chinese medicine Shengmai ...

While we did not assess the expression of T1R1, it is conceivable that T1R1+T1R3 heterodimers in the distal oesophagus might function as an l-amino acid ... GLP-1 secretion. This would be consistent ...

The sequences of the primers for ... variants at the transcript (ENST00000351747.2) and protein levels (Q6ZR08-1). MT-like, Microtubule-binding-like domain. (C) Conservation analyses of affected amino ...