For example, the estimated glomerular filtration rate (EGFR) indicates possible kidney disease when it drops below a 60 milliliter (ml) per minute rate. Other tests include the blood urea nitrogen ...

Having creatinine levels in your blood above 1.2 mg/dL for males and 1.0 mg/dL for females may indicate a potential issue with your kidneys, such as an infection or kidney disease. Creatinine is a ...

An EGFR gene mutation is one of the biomarkers a doctor often tests for after confirming a diagnosis of non-small cell lung cancer (NSCLC). Biomarkers can help guide treatment. EGFR mutations ...

Fibroblast growth factor (FGF) signaling elicits multiple downstream pathways, most notably the Ras/MAPK cascade facilitated by the adaptor protein Grb2. However, the mechanism by which Grb2 is ...

Department of Respiratory and Critical Care Medicine, National Health Commission (NHC) Key Laboratory of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science ...

Moreover, DENND1A binds to the N-terminal and C-terminal SH3 domains of Grb2 through PRD. Of special interest is the observation that EGFR can recruit Grb2-DENND1A complex under EGF stimulation.

After normalization, EGFR no longer dominated binding. Only three domains (GRB2, SHCA PTB and to a lesser extent ARG) displayed a greater relative affinity for EGFR than would be expected from ...

BRET was used to assess, in live cells and real-time, the physical interaction between hIR and insulin receptor signaling proteins (IRS1) and the growth factor receptor-bound protein 2 (Grb2). Our ...