Researchers have identified an early postnatal window that allows gene transfer to circulating blood stem cells, advancing ...

Stem cells can produce any other cell type, it is just a matter of telling them in the right way. From a biological ...

Led by Lars Velten, PhD, group leader at the CRG, the study designed enhancers with specificity to user-defined combinations of hematopoietic ... In blood stem cell differentiation, single-cell ...

This myeloid/platelet-biased differentiation disrupts normal ... Currently, Dr. Iwama’s lab is focused on aging of hematopoietic stem cells and aged-associated hematological malignancies.

During development, the differentiation of stem cells is ... Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan, Blood (2025).

Of particular scientific interest are hematopoietic stem cells (HSCs), which ... This myeloid/platelet-biased differentiation disrupts normal blood cell production (hematopoiesis) and can ...

More information: Hana Komic et al, Continuous map of early hematopoietic stem cell differentiation across human lifetime, Nature Communications (2025). DOI: 10.1038/s41467-025-57096-y ...

When they analyzed the transcriptomic profiles of these cells using dimensionality reduction approaches, they found signatures of different cell types and differentiation ... Engineering a niche ...

neuroinflammation and β-amyloid build-up in Alzheimer’s mice Systemic transplantation of wild-type hematopoietic stem and progenitor cells (green) led to their differentiation into microglia-like ...

Flow cytometric analysis and colony assays were performed to assess the hematopoietic differentiation capacity of hiPSCs. Here, we reveal human umbilical arterial endothelial cell–derived induced ...

Furthermore, processes such as homing, proliferation, and differentiation of HSCs are strongly controlled by the BM niche and have been reported to be related to the success of hematopoietic stem cell ...