Neuroinflammation significantly contributes to stroke pathophysiology, leading to tissue damage and neurological deficits. Baicalein, a potent 12/15-LOX (12/15-lipoxygenase) inhibitor, demonstrates ...

Results We showed that hypoxia enhanced the stemness of HCC cells and hepatocarcinogenesis through enhancing HIF-1α deSUMOylation by SENP1 and increasing stabilisation and transcriptional activity of ...

Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (C.W., W.X., S.J., Y.W., J ...

7 In pancreatic β-cells, GLP-1R activation by semaglutide enhances glucose catabolism and insulin secretion via the mTOR-dependent HIF-1α pathway ... also activates the AMPK pathway, promoting ...

and block the AMPK/Skp2/Parkin and PI3K/AKT/mTOR pathways to inhibit cancer cell proliferation and induce cancer cell apoptosis, autophagy and/or ferroptosis. Moreover, Tan IIA can decrease the ...

Meanwhile, exogenous NO also promotes the stabilization of HIF-1α and plays a certain role in maintaining ... the function of mTORC1 is inhibited. PTEN and AMPK are the two main ways of inhibiting ...

Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1 activation down-modulates LD catabolism mediated by adipose triglyceride lipase (ATGL), the key enzyme for intracellular ...

AMP-activated protein kinase (AMPK) activity and gene expression were ... solution (I9278), antibody to hypoxia-inducible factor (HIF-1α, H6536) and sodium sulfite (Na 2 SO 3, S0505) were ...

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are ...