News

PNAS3d
Functional and physical interaction between yeast Hsp90 and Hsp70
A. Bolon and Jeffrey L. Brodsky) The Hsp90 molecular chaperone remodels and activates a large variety of client proteins. Its activity requires collaboration with the more than 25 Hsp90 cochaperone ...
C&EN6d
Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90–Kinase Interactions
Find more information on the Altmetric Attention Score and how the score is calculated. Heat shock protein 90 (Hsp90) is a ubiquitous chaperone of all of the oncogenic tyrosine kinases. Many Hsp90 ...
C&EN13d
Hsp90 Inhibitors, Part 2: Combining Ligand-Based and Structure-Based Approaches for Virtual Screening Application
Find more information on the Altmetric Attention Score and how the score is calculated. Hsp90 continues to be an important target for pharmaceutical discovery. In this project, virtual screening (VS) ...
The Lancet26d
FaceAge, a deep learning system to estimate biological age from face photographs to improve prognostication: a model development and validation study
aArtificial Intelligence in Medicine Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA bDepartment of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer ...