Structure of the lysosomal chloride-proton transporter CLC ... Hite R.K. (2023) “Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor.” Nat Commun. 14(1):6897. Oh S ...

This sex-specific difference may be closely associated with variations in the production of inositol 1,4,5-triphosphate (IP3) and the activation state of its corresponding receptor (IP3R ... disrupts ...

and by studying receptors directly from human brains, this research provides new insights into their exact structure, including how they interact with specific drugs," said study senior author ...

In a study published in Cell, a research team led by Zhu Shujia from the Center for Excellence in Brain Science and ...

Study of 2.4 million participants reveals potential advantages for cardiometabolic and psychiatric conditions alongside increased risks of gastrointestinal and musculoskeletal issues Study ...

When you first enter a new world, you can either spawn near a structure or find one while exploring any of the three dimensions. While finding some can be quite easy, others are extremely hard to ...

The team believes that the structure was in use until the 8th century BCE, the middle of the period when the Kings of Judah ruled. A scarab seal from the 8th century BCE uncovered during the ...

Antipsychotics are commonly used in treating psychiatric disorders. These medications primarily target dopamine the serotonin receptors, they have some affinity to adrenergic, histamine, glutamate and ...

Caffeine blocks physiological intracellular Ca 2+ oscillations by inhibition of inositol 1,4,5-trisphosphate receptor-(IP 3 R)-mediated signalling. Sustained cytosolic Ca 2+ overload from abnormal Ca ...

Centre for Endocrinology, William Harvey Research Institute, Bart’s and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, U.K. School ...