The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

The intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making structure prediction particularly challenging.

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs).

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Northwestern University researchers have identified structural features in engineered cell receptors that correlate with variations in receptor function. Computational protein structure prediction ...

Ryanodine Receptor type 3 mediates ER Ca2+ release in different cell types. Here, the authors use cryo-EM to reveal a binding site for chloride and two distinct sites for ATP. Epileptic ...

Figure 1. 3D-structure of the TCR-pMHC complex. (1G4 TCR bound to NY-ESO-1/HLA-A201, entry 2BNR (124) of the PDB). TCRα, TCRβ, MHC, and b2-microglobulin are colored in blue, cyan, orange, and green, ...

Many studies have shown that chemokine receptor dysregulation is an important cause of impaired neutrophil migration, and the vast majority of these chemokine receptors belong to the G protein-coupled ...

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7365, United States ...

The healthy cells receive a low dose or no radiation. Special scans can check whether your NET has these receptors. If your NET has somatostatin receptors, doctors can use these receptors to target ...

Figure 1. Signal transduction mechanism of EGFR (epidermal growth factor receptor) transactivation by angiotensin II (AngII) in vascular smooth muscle cells leading to vascular remodeling. Please note ...