cch.aphp.fr Objectives Pulmonary arterial hypertension (PAH) is characterised by remodelling of pulmonary arteries with enhanced vascular smooth muscle cell (VSMC ... scleroderma-associated PAH and ...

B-cell prolymphocytic leukemia (B-PLL) is a rare, aggressive type of leukemia that progresses rapidly. People with B-PLL typically have a less favorable outlook. However, new targeted treatments ...

Previous studies have shown they may interact with our hormones, or enter our cells and disrupt our DNA ... which could cause prolonged obstructions to blood flow in the brain.

Patient & methods: As part of routine medical care, the author monitored total and IgG subclass levels ... After being switched to daily SCIg therapy, the headaches stopped, and her annual ...

We study the role of T cells in mBC responses, using CD40L stimulation and autologous T-B co-cultures. Our results showed that increased CD40L levels led to a selective increased proliferation of IgM+ ...

Non-Hodgkin lymphoma (NHL) is generally divided into 2 main types, based on whether it starts in B lymphocytes (B cells) or T lymphocytes (T cells). There are many different types of B-cell lymphomas.

In particular, it highlights the role of Kidins220 in extending B cell survival so as to increase the time available for the λ light chain locus to open for VJ recombination, it also shows that ...

Our results showed that the TLRs-induced B cell proliferation and activation was significantly impaired in AD-HIES patients. Besides, AD-HIES patients had defects in TLRs-induced B cell class switch, ...

Of the five classes of antibodies produced by B cells in mammals, IgG is the major class of antibodies in the blood. IgG activates complement, and binds Fc-receptors (FcRs) on macrophages and ...

B lymphocytes use B cell receptors (BCRs) to sense the physical features ... In contrast, the activation of isotype-switched IgG- or IgE-BCR only requires a low threshold of less than 12 pN, providing ...