A meaningful rank of NSAIDs in terms of inhibition of COX should take into account the complexities inherent in biochemical systems, including the mechanism of catalysis of the endogenous substrate.
Role of the cyclooxygenase isoforms (COX-1 and COX-2) in the production of the constitutive and inducible eicosanoids (prostaglandins, thromboxane and leukotrienes). The primary function of each ...
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Celebrex vs. Ibuprofen: Which Is Best for You?Celebrex works by blocking the COX-2 enzyme, which plays a crucial role in synthesizing prostaglandins that cause pain and ...
The mechanism of action of indomethacin, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Use lowest effective dose for shortest ...
Inhibition of these activities is responsible for most of the side effects of NSAIDs. NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively ...
All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...
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