All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...
Role of the cyclooxygenase isoforms (COX-1 and COX-2) in the production of the constitutive and inducible eicosanoids (prostaglandins, thromboxane and leukotrienes). The primary function of each ...
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Celebrex vs. Ibuprofen: Which Is Best for You?Celebrex works by blocking the COX-2 enzyme, which plays a crucial role in synthesizing prostaglandins that cause pain and ...
The mechanism of action of indomethacin, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Use lowest effective dose for shortest ...
Inhibition of these activities is responsible for most of the side effects of NSAIDs. NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively ...
"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...
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