Low back pain is the most prevalent musculoskeletal condition worldwide and is closely tied to the progressive degeneration ...

As populations worldwide continue to age, chronic back pain caused by intervertebral disc degeneration is emerging as a widespread and costly health ...

Department of Orthopedic Surgery, Columbia University, 650 West 168th Street, 1410, New York, New York 10031, United States Department of Biomedical Engineering, Columbia University, 650 West 168th ...

Our spine represents a combination of discs and vertebrae; between each two vertebrae, we can find an intervertebral disc. We will be interested in this paper to the lumbar discs, which are the most ...

The outer portion of the disc (the annulus fibrosus) is made up of a tough fibrocartilage. The middle section (the nucleus pulposus) is composed of water and collagen and has a gelatinous consistency.

In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles of 37 disc tissue samples obtained from ...

Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea Biomedical Physics Laboratory, Frontier Physics Research Division, Seoul National ...

With age, the intervertebral disk may lose fluid and become dried out ... As the disk continues to break down, or with continued stress on the spine, the inner nucleus pulposus may actually rupture ...

The transient dynamics of these fracture have been studied through in vitro experiments coupled with numerical simulations, but no direct observation have ever been made of their genesis and evolution ...