Stem-cell derived organoids provide the perfect mixture of cells to rebuild damaged intestines.

The intestinal epithelium exhibits the highest ... Driven by growth factors and cytokines derived from the stem cell niche and surrounding immune cells, multiple signaling pathways tightly ...

which are thought to make up the intestinal stem cell niche. Remarkably, their culture conditions can also be used to promote long-term growth of intestinal epithelium beginning from just a single ...

Blood stem cells and intestinal stem cells for example constantly produce new progeny. In contrast to this, muscle stem cells are normally quiescent and activate only if they receive a signal of ...

Impact of the stem cell niche on aging: we study the communication between stem cells and their niche (e.g. neighbor cells, ECM) in multiple tissues including the intestine, mammary, skeletal muscle, ...