Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances on the field and his determination to play despite a recent foot injury.

Game status: Isaac Guerendo is ACTIVE for Week 15 against the Rams. The San Francisco 49ers host the Los Angeles Rams in a Week 15 Thursday Night Football game that is a must-win for both teams.

Unfortunately, that didn't prove to be the case. Less than two minutes into the game, San Francisco's third-choice running back Isaac Guerendo suffered a left knee injury after it was twisted at ...

Coach Kyle Shanahan said Guerendo (foot/hamstring) will be limited at Thursday's practice, Cam Inman of The San Jose Mercury News reports. As Shanahan projected Monday, Guerendo is returning to ...

San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday. Guerendo ...

San Francisco 49ers running back Isaac Guerendo's second touchdown of day gets 49ers to 30-point mark vs. Chicago Bears. Watch the highlights from Super Bowl LIX between the Kansas City Chiefs and ...

San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their "Sunday Night Football" road game against the Buffalo Bills in Week 13 ...

San Francisco 49ers running back Isaac Guerendo was forced to exit Sunday's game against the Arizona Cardinals during the first offensive drive. The rookie was carted off the field, and the team ...

The Fantasy Football Podcast crew all believe Isaac Guerendo is in a great position as the 49ers lead back in Week 16 vs. the Dolphins.