Outcomes of Frontline Triplet Regimens With a Hypomethylating Agent, Venetoclax, and Isocitrate Dehydrogenase Inhibitor for Intensive Chemotherapy–Ineligible Patients With Isocitrate ...

Alginate lyase is a critical enzyme that catalyzes alginate degradation; however, its low thermal stability limits its industrial application. This study proposes a feasible and efficient rational ...

A study has identified a new target for Group-3 medulloblastomas. Medulloblastomas are one of the most common childhood brain cancers. Particularly, Group-3 medulloblastomas are aggressive and ...

The escalation of antibiotic resistance underscores the need for innovative approaches to combat bacterial infections. Phage therapy has emerged as a promising solution, wherein host determination ...

A research paper just published in Science China Life Sciences reports that pectin lyase secreted by Phytophthora sojae and its degradation products, pectin oligosaccharides, exhibit dual immune ...

We have developed two monoclonal antibodies, CPTC-2MeSC-1 and CPTC-2MeSC-2, against itaconate and its conjugates with sulfhydryl-containing biomolecules such as cysteines. Itaconate is a dicarboxylic ...

Somatic monoallelic single nucleotide variants in the genes that encode isocitrate dehydrogenase (IDH) 1 and 2 are found in a large subset of diffusely infiltrating gliomas and subsets of acute ...

Mutations in isocitrate dehydrogenase (IDH) genes, an early step in the ontogeny of lower-grade gliomas, induce global epigenetic changes characterized by a hypermethylation phenotype and are critical ...