The Connectivity map approach identified AZ-628 as a potent RIP3 inhibitor whose inhibition of RIP3 kinase activity abolished OA pathogenesis ... phospho-Receptor-interacting protein kinase 1 (p-RIPK1 ...

Bruton’s tyrosine kinase (BTK) is known to regulate multiple anti-apoptotic ... The primary antibodies against BTK (phospho Y223), Mcl-1, Bim and β-actin were purchased from Abcam Inc. (Cambridge, MA, ...

The purpose of this study was to investigate if exertional rhabdomyolysis induced by an acute bout of plyometric exercise in untrained individuals was associated with histological characteristics of ...

Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single ...

In frame translation initiation sites within coding sequences drive the expression of N-terminally truncated proteoforms.

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

However, the clinical efficacy of mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi ... to evaluate the relationship between MAP2K1 mutation class and clinical activity of MAPKi. We ...

In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity that in most cases derives from spontaneous dimerization induced by the different ...

Can physical activity extend the lifespans of older adults? A review article published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi ...

However, the study provides limited new insights into the relationship between retinal lamination defects and overall retinal function. Neural lamination is a common feature of the central nervous ...

Researchers at the Harvard Medical School discovered that the enzyme GUK1 promotes lung cancer growth by boosting the ...

Development of genetically encoded fluorescent biosensor allows real-time visualization of PKN kinase activity, revealing sustained activity at the plasma membrane and demonstrating a new approach ...