eLife15d
Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition
Endosomes and lysosomes form giant structures in the periphery of the ... early 2-cell (E2C: 24 hpf), and late 2-cell (L2C: 40 hpf) embryos were fixed and stained with anti-LAMP1 antibody.
Frontiers9d
Endosomal trafficking inhibitor EGA can control TLR7-mediated IFNα expression by human plasmacytoid dendritic cells
Another recent study (20) also reported that an inducible VAMP3 + LAMP2 + LAMP1 − endolysosome compartment exists in human pDCs from which TLR9 activation triggers type 1 interferon expression, ...
Frontiers11d
The interplay between autophagy and cGAS-STING signaling and its implications for cancer
RAB22A-induced autophagosomes fuse with early endosomes, while inhibiting RAB7-mediated fusion with lysosomes. Secretion of the RAB22A ... especially in combination with tumor hypoxia (230). In ...
ALZFORUM29d
Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Other variants shift AD risk in East Asians and Europeans. SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia. Where does the field stand now, 18 months later? On the ...
RTE Online29d
Here are tonight's Late Late Show guests
It's the Late Late Show GAA Special on Friday night with All-Ireland-winning captains, GAA President Jarlath Burns, Evanne Ní Chuilinn, Pat Spillane, and The 2 Johnnies among Patrick Kielty's guests.
The Motley Fool29d
Think It's Too Late to Buy Joby Aviation? Here's the Biggest Reason Why There's Still Time.
Joby Aviation produces electric vertical takeoff and landing aircraft. Shares of the upstart company have soared over the past year. Yet, Joby still hasn't commenced commercial operations. However ...
eLife9d
Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani
The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...
Nature12d
The known unknowns of antigen processing and presentation
These structures are modified over time and ultimately fuse with lysosomes to form phagolysosomes ... which is present in the endosomes of plasmacytoid DCs 37. As TLR signalling is a well-known ...
The New York Times25d
Benfica 4 Barcelona 5: Late winner, Szczesny errors, penalties, a hat-trick and an own goal in thriller
Raphinha scored a late and controversial winner as Barcelona came from behind to win a remarkable game 5-4 against Benfica and qualify for the knockout stage of the Champions League. The last ...
CNBC17d
Credit card late fees cost Americans billions a year — now they're capped at $8
New government regulations are slashing the late fees charged by many credit card companies. On March 5, 2024, the Consumer Financial Protection Bureau (CFPB) finalized a rule limiting the penalty ...
RTE Online7d
Be in The Late Late Show Studio Audience!
The Late Late Show is back on your screens this Autumn for a brand-new season with host Patrick Kielty! Patrick will be joined by a host of special guests each Friday night in front of a live ...