The authors study how apolipoprotein L1 variants impact inflammation and lipid accumulation in macrophages. The findings will be useful for researchers investigating macrophage metabolism and ...

“This research shows that people with COPD seem to gather a lot more carbon in their lung cells. These cells also look and ...

Multimodal characterization of single cells offers unprecedented resolution and depth for research in fundamental biology, pathology, and drug development. However, limited by labeling techniques or ...

Cardiac macrophages surround cardiomyocytes and capture dysfunctional mitochondria that these cells eject to the milieu, effectively establishing a client cell–support cell interaction. We refer to ...

Results By comparing the immune and inflammatory responses between wt and CD131-deficient mice, we found that CD131 contributed to DSS-induced murine colitis, which functioned in synergy with tissue- ...

When the macrophages’ ability to consume dying cancer cells or Upd3 production was decreased, tumor growth was significantly reduced.

Modulating gene expression in macrophages can be used to improve tissue regeneration and redirect tumor microenvironments (TMEs) toward positive therapeutic outcomes. We have developed Bacillus ...

We propose that senescent cells may express immune checkpoint and integrin-like proteins that can help them escape immunosurveillance, allowing the SASP to disrupt the phagocytic function of ...