After the administration of a single dose of the drug to this patient, the urine was examined for carbonic anhydrase inhibitor activity. Seventy-two per cent of the administered drug was recovered ...

Sulthiame is an investigational, generally well-tolerated oral carbonic anhydrase inhibitor that is designed to restore breathing stability which is often a contributing mechanism in people with OSA.

Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved in cancer progression and survival. Targeting CA IX with selective inhibitors like SLC-0111 has shown therapeutic ...

Identifying suitable targets for a dual inhibitor approach requires a deep understanding of disease biology, knowledge of critical pathways, and selection of complementary or synergistic targets.

(2024). Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry, 279 ...

Hypoxia in tumors contributes to chemotherapy resistance, worsened by acidosis driven by carbonic anhydrases ... of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale) D-06120 ...

The researchers identified carbonic anhydrase inhibitors as a promising option for reducing tau toxicity. Tauopathies are a group of neurodegenerative diseases caused by the accumulation of tau ...

University of Vienna. (2024, May 16). Breaking bonds to form bonds: Rethinking the Chemistry of Cations. ScienceDaily. Retrieved May 30, 2025 from www.sciencedaily.com / releases / 2024 / 05 ...

Clinical-stage generative artificial intelligence (AI)-driven drug discovery company Insilico Medicine (“Insilico”) announced a novel small molecule CDK8/19 inhibitor designed using the ...

Clinical stage generative artificial intelligence (AI)-driven biotechnology company InSilico Medicine ("InSilico"), today announced that the Journal of Medicinal Chemistry, an ACS Publications ...