Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

ERBB receptors are regulated by their own intrinsic properties as well as by external associated proteins. What is regulation, where does it occur on the receptor, and how do scientists study it?

One group of proteins working in such specialized environments are the membrane receptors, which act like biological "antennas," sensing signals from the environment and triggering cellular responses.

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology, transforming protein engineering.

Supercomputer simulations have revealed how changes in the shape of the HIV-1 capsid protein may help the virus squeeze its ...

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve ...

To switch on the cell death signal, just 15% of all CD95 receptors on the cell membrane need to bind in twos or threes around ...

Researchers at the Center for Life Sciences at the Paul Scherrer Institute PSI have for the first time identified structural ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now discovered that CAR molecules can be transferred from the CAR-T cells to ...

HHMI researchers discover that protein related to snake venom toxin ... physiologists had told us they weren’t really sure that a membrane-bound molecule like lynx-1 could even access the receptor,” ...