Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve ...

One group of proteins working in such specialized environments are the membrane receptors, which act like biological "antennas," sensing signals from the environment and triggering cellular responses.

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...

Integral membrane proteins such as receptors and ion channels span the membrane. Peripheral membrane proteins, for example some signalling proteins, are tethered by an anchor, via a fatty acid ...

Opioid use during pregnancy—whether of highly addictive drugs like fentanyl or controlled opioids like buprenorphine—doubles ...

Researchers at the Center for Life Sciences at the Paul Scherrer Institute PSI have for the first time identified structural ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology, transforming protein engineering.

Peptides, as versatile biomolecules, continue to gain traction in various scientific fields due to their wide range of biochemical and physiological impacts. Among these, ABP-7 peptide has emerged as ...

Tweaking the spacing between binding domains on the ECM surrounding cancer cells can boost their killing via ultrasound ...