BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

The DNA within mitochondria needs to be replicated as new mitochondria are made. Mitochondrial DNA must also be repaired after factors like oxidative stress damage it. However, around 300 ...

“While mtDNA is much smaller than nuclear DNA, it plays a crucial role in life forms through energy production. During my graduate studies, I investigated mitochondrial transfer ribonucleic acids ...

However, how mitochondrial DNA (mtDNA) contributes to cancer has been unclear. Scientists at St. Jude Children's Research Hospital studied varying levels of mutated mtDNA to see their effect on ...

Mitochondrial DNA depletion syndrome (MTDPS) is a rare genetic disorder characterized by a marked decrease in mitochondrial DNA (mtDNA). This condition can cause symptoms including muscle weakness ...

Glioblastoma cells are known to have high mitochondrial ... TUNEL staining shows that the expression of ATP5⍺-AT3 and ATP5⍺-AT20 can block STS (1 µM)-induced apoptosis in GBM cells. TUNEL-Cy3 was used ...

Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts. PLOS Biology , 2024; 22 (8): e3002723 DOI: 10.1371/journal.pbio.3002723 Cite ...

There are two types of mitochondrial disease. One is caused by faulty genes in the nuclear DNA, the DNA we inherit from both our parents and which makes us who we are. The other is caused by ...

The quality and amount of mitochondrial DNA (mtDNA) and RNA (mtRNA ... at 20 μm onto slides that contained one section from each timepoint for parallel staining and analysis; slides were stored at ...

Assessed on blood samples from patients with Parkinson’s disease, the PCR-based assay (Mito DNA DX) identifies mitochondrial DNA (mtDNA) damage and could feasibly be used to help measure ...

each mitochondrion carries 10 or so copies of circular mitochondrial DNA (mtDNA), totaling up to thousands of these genomes per cell. They can exist as a mixture of mutant copies and normal wild ...

The expression level of mitochondrial DNA (mtDNA) was detected by real-time PCR ... Were Reversed by Suppression of the JNK/Sab Signaling Pathway DAPI and Nile red double staining were performed on ...