"Our study began when we noticed a key gap in our understanding of how neural circuits in the limbic system ... and fear-based learning, the PFC, NAc and BLA. "We found that in mPFC, cues ...

This behavioral shift is driven by distinct brain circuits involving dopaminergic neurons in the ventral tegmental area. Male mice show different neural pathways for female ... VTA DA projections to ...

"The results of this work provide the neural circuitry basis for BLA-NAc and PVT-NAc glutamate projection ... input-defined parallel nucleus accumbens circuits in mice, Nature Communications ...

Maladaptive changes in the neural circuits associated with reward and aversion result ... of reward and aversion in certain brain regions, including the NAc, VTA, BF, and LH. A loss-of-function study ...

Overall, this study provides a valuable and solid resource with which to investigate neural circuits involved in motivated behaviors. Therefore, we have begun to describe the prefrontal innervation of ...

Targeting these circuits ... PF thalamus to the NAc were also interrupted, and that this led to depression-like symptoms in the mice, including loss of motivation. Using chemogenetics or optogenetics, ...

In the case of brain circuits, these connections between different brain regions mediate neural activity: if one brain region is activated, it will send information to the other brain regions it is ...

We conclude that DA axonal transmission is unlikely to be mediated via classical synapses in the NAc and that the major locus of anatomical plasticity of DA circuits after exposure ... as an ...

Department of Health Sciences and Technology, ETH Zürich, Zurich, Switzerland Across sleep and wakefulness, brain function requires inter-neuronal interactions lasting beyond seconds. Yet, most ...

or vehicle were made in the hedonic hotspot of the NAc shell to activate NAc-VP circuits immediately before the test, and VP neural firing was recorded to all stimuli. For serial Pavlovian tests, ...