The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

The partnership aims to provide game-changing luminescent lanthanide-based oligo probes for diagnostics and life science research applications. MORRISVILLE, N.C. and BERKELEY, Calif., May 19, 2025 ...

This is done without the need for nucleic acid amplification ... triggering a positive feedback loop that results in a high signal-to-noise ratio. The test demonstrated unprecedented sensitivity.

(2) Signal amplification systems can be broadly categorized into enzymatic and nonenzymatic approaches. Enzymatic amplification methods, such as polymerase chain reaction (PCR), rolling circle ...

The novel neuromorphic approach helps implement an on-chip learning mechanism through analogue signal processing ... The burst frequency produced on amplification depends on the change in pH ...

A nucleic acid aptamer is essentially a segment of oligonucleotide ... high specificity are screened after dozens or tens of rounds of binding, isolation, and amplification in three steps [10] .

In this perspective, we review recent advances in electrochemical biosensor signal amplification strategies for infectious disease diagnostics, specifically biosensors for nucleic acids and pathogenic ...

Nucleic acid amplification technologies (NAATs ... and specific reactions were the driving forces behind the development of these methods. ⁃ Signal-Mediated Amplification of RNA Technology ...