More and more functions of nucleic acids are discovered in vitro and in ... modified nucleotides with non-canonical three-dimensional structures remains very challenging. Here, the authors design ...

Levene made his initial proposal in 1919, discrediting other suggestions that had been put forth about the structure of nucleic acids. In Levene's own words, "New facts and new evidence may cause ...

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...

Scientists have identified sequences in great apes' DNA capable of forming unconventional structures called non-B DNA. These ...

This fundamental study combines in vitro reconstitution experiments and molecular dynamics simulations to elucidate how membrane lipids are transported from the outer to the inner membrane of ...

The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

Nucleic acid nanoparticles (NANPs) are promising immune modulators due to their well-established structural properties and distinct structure–activity relationship with the immune system. We ...

Financial support from the Agence nationale de recherche sur le sida et les hépatites virales (ECTZ158948 to A.B. and ECTZ143165 to M.L.) and the China Scholarship Council (202008620095) is gratefully ...

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States ...

A new concept of kinetic modules in biochemical networks could revolutionize the understanding of how these networks function ...