This naturally-occurring nucleoside analogue has been used to treat inflammatory disease and cancer for hundreds of years, but runs into several barriers that severely limit its effectiveness when ...

The authors explain that semaglutide likely operates immediately via calorie restriction and activation of adenosine monophosphate-activated protein kinase (AMPK), which essentially controls the ...

Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhea. It’s usually cured with antibiotics. Gonorrhea can affect people of any age, anatomy, or gender ...

If you're getting treated for an HIV infection, your doctor may suggest a type of drug called an NRTI. It's short for "nucleoside/nucleotide reverse transcriptase ...

This increases a substance in your body called cyclic adenosine monophosphate (cAMP). cAMP signals your immune system to stop releasing substances that promote inflammation. It also tells your ...

The equilibrative nucleoside transporter 3 (ENT3) appears to support microglial function and play a protective role against the progression of Huntington disease (HD), according to a study published ...

Since the early days of the COVID-19 pandemic, researchers have been working on an oral antiviral drug of the parent nucleoside of remdesivir that could stop replication of the virus. "Oral ...

• Sarcoma is a complex malignancy, characterized by numerous subtypes each with a unique biology/immune microenvironment; therefore, a histology-specific approach is required for immuno-oncology drug ...

In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleotide monophosphate. Activation by this route circumvents highly selective ...

Abstract: The self-assembly of the nucleoside guanosine monophosphate (GMP) into complex DNA secondary structures, in aqueous solution is concentration and temperature dependent. It is a unique ...

Medicine Nobel 2023 awarded to Katalin Karikó, Drew Weissman for their work in mRNA vaccines Dr. Karikó and Dr. Weissman were awarded the prize for their “discoveries concerning nucleoside ...