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Data are means ± SE. Relative changes of indicated transcripts and immunoblots of indicated proteins in cultured C57Bl/6 islet extracts treated with PBS or 20 nmol/l exendin-4 for 0, 2, 4, 6, 8 ...

If your type of breast cancer is hormone-receptor-positive and HER2-negative, then you may be treated with CDK4/6 inhibitors. They are a newer class of medicines used to treat breast cancers and ...

CDK4/6 inhibitors are targeted drugs that can be used for women with a common type of breast cancer: hormone receptor-positive and HER2-negative. Currently, there are three CDK4/6 inhibitors approved ...

The Rajshahi University administration has decided to reduce the dependent quota – fixed for the children of the university's teachers and employees – for admission from the existing 4% to 1%. The ...

President Ferdinand Marcos Jr. has vetoed or removed at least P16.7 billion worth of flood control projects in various regions nationwide under the P6.326 trillion national budget for 2025 which he ...

p27 phosphorylation at Thr157 and Thr198 by members of the AGC kinase family promotes assembly of p27–cyclin D–CDK4/6, but catalytic activation requires tyrosine phosphorylation. Cytoplasmic ...

Chizoba Morah is a business owner, accountant, and recruiter, with 10+ years of experience in bookkeeping and tax preparation. Erika Rasure is globally-recognized as a leading consumer economics ...

Provided herein are novel compounds as CDK2 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds. Cyclic-dependent kinase 2 ...

The Canada Pension Plan (CPP) children's benefits provide monthly payments to the dependent children of disabled or deceased CPP contributors. There are 2 types of CPP children's benefits: a disabled ...

Flow cytometry was used to detect cell cycle changes. The mRNA levels of cyclin D1, CDK4, and c-myc were detected by RT-PCR. The protein expression levels of β-catenin, cyclin D1, CDK4, c-myc, ...