Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Two months after the last chemotherapy, Bianca Balti resumes her battle against cancer. Fresh from participating in the Milan ...

Pfizer Ltd has announced that the Scottish Medicines Consortium (SMC) has accepted Talzenna (talazoparib) in combination with ...

When a double strand of DNA is broken into a single strand, or damaged, PARP enzymes rush in to repair the damage so the cell can continue to grow and thrive. “PARPs are almost like repair trucks that ...

A pilot study was performed to assess potential dose-related toxicities of DNA-PK inhibitor NU7441 (2, 4, or 8 mg/kg IP once daily) in combination with PARP inhibitor olaparib (25 mg/kg, oral gavage ...

This enzyme is key to DNA repair in cells, so blocking it leads to cell death. Though PARP inhibitors are already approved to treat certain cancers, they come with toxicity risks thought to be ...

PARP inhibitors target the DDR PARP enzymes support single strand break repair and prevent formation of DNA double strand breaks (DSBs) during replication. Repair of these DSBs requires homologous ...

Finally, we show that in response to type I interferon stimulation, MARUbylation can occur endogenously on PARP targets. Thus, MARUbylation represents a new dual PTM that broadens our understanding of ...