DNA polymerases carry out crucial functions in many DNA metabolic processes. Polymerases catalyse the addition, using a template, of complementary nucleotides to the 3′ end of DNA primer strands.

For some years, Mahesh Varia and James Raleigh (University of North Carolina at Chapel Hill, NC, USA) have used pimonidazole as a marker of tumour hypoxia, with a view to predicting which patients ...